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Funcionalización selectiva de enlaces c(sp3)–h alifáticos usando amidas como grupos directores y sistemas reactivos basados en yodo hipervalente/yodo: formación de enlaces c–n mediante transferencia intramolecular de átomos de hidrógeno
dc.contributor.advisor | González Martín, Concepción del Carmen | |
dc.contributor.advisor | Herrera González, Antonio Jesús | |
dc.contributor.advisor | Cosme García, Francisco | |
dc.contributor.author | Rodríguez Sosa, Dionisio José | |
dc.contributor.other | Programa de Doctorado en Química e Ingeniería Química | |
dc.date.accessioned | 2021-12-02T13:27:39Z | |
dc.date.available | 2021-12-02T13:27:39Z | |
dc.date.issued | 2016 | |
dc.identifier.uri | http://riull.ull.es/xmlui/handle/915/26030 | |
dc.description.abstract | Throughout this thesis it is described our research on the functionalization of unactivated C(sp3)-H bonds, mainly from methyl groups, in nonconstrained molecules, to create new C(sp3)-N and C(sp3)-Br bonds. They were conducted through 1,5 hydrogen atom transference to nitrogen centered radicals, generated by treatment with the reactive systems PhI(OAc)2/I2 or PhI(OAc)2/Br2 under irradiation of several precursors such as sulfonamides, cyclic sulfamates and cyclic sulfamides. All these precursors allowed the regio- and chemoselective synthesis of pyrrolidines, g-lactams and cyclic imines. The mechanisms of the functionalizations and the oxidation to imines were also investigated in order to improve the chemoselectivity. The evidence obtained let us propose a mechanistic pathway to explain the formation of each product. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | es | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Funcionalización selectiva de enlaces c(sp3)–h alifáticos usando amidas como grupos directores y sistemas reactivos basados en yodo hipervalente/yodo: formación de enlaces c–n mediante transferencia intramolecular de átomos de hidrógeno | es_ES |
dc.type | info:eu-repo/semantics/doctoralThesis | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject.keyword | Mecanismos de reacción | es_ES |
dc.subject.keyword | Radicales libres | es_ES |
dc.subject.keyword | Química orgánica | es_ES |
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