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High Plasma levels of sTnF-r1 and ccl11 are related to cD4+ T-cells Fall in human immunodeficiency Virus elite controllers With a sustained Virologic control.
dc.contributor.author | Valenzuela Fernández, Agustín | |
dc.contributor.author | Gutiérrez Rivas, Mónica | |
dc.contributor.author | Jiménez Sousa, María Ángeles | |
dc.contributor.author | Rallón, Norma | |
dc.contributor.author | Jiménez, José Luis | |
dc.contributor.author | Restrepo, Clara | |
dc.contributor.author | León, Agathe | |
dc.contributor.author | Montero Alonso, Marta | |
dc.contributor.author | González García, Juan | |
dc.contributor.author | Muñoz Fernández, María Ángeles | |
dc.contributor.author | Benito, José Miguel | |
dc.contributor.author | Resino, Salvador | |
dc.contributor.other | Medicina Física y Farmacología | |
dc.contributor.other | Grupo "Inmunología Celular y Viral". | |
dc.date.accessioned | 2024-01-15T21:07:40Z | |
dc.date.available | 2024-01-15T21:07:40Z | |
dc.date.issued | 2018 | |
dc.identifier.uri | http://riull.ull.es/xmlui/handle/915/35342 | |
dc.description.abstract | Our aim was to analyze the relationship between plasma inflammatory biomarkers and CD4+ T-cells evolution in human immunodeficiency virus (HIV) elite controllers (HIVECs) with a suppressed viremia. We carried out a retrospective study in 30 HIV-ECs classified into two groups: those showing no significant loss of CD4+ T-cells during the observation period (stable CD4+, n = 19) and those showing a significant decrease of CD4+ T-cells (decline CD4+, n = 11). Baseline plasma biomarkers were measured using a multiplex immunoassay: sTNF-R1, TRAIL, sFas (APO), sFasL, TNF-α, TNF-β, IL-8, IL-18, IL-6, IL-10, IP-10, MCP-1, MIP-1α, MIP-1β, RANTES, SDF1α, GRO-α, and CCL11. Baseline levels of sTNF-R1 and CCL11 and sTNF-R1/TNF-α ratio correlated with the slope of CD4+ T-cells (cells/μl/year) during follow-up [r = −0.370 (p = 0.043), r = −0.314 (p = 0.091), and r = −0.381 (p = 0.038); respectively]. HIV-ECs with declining CD4+ T-cells had higher baseline plasma levels of sTNF-R1 [1,500.7 (555.7; 2,060.7) pg/ml vs. 450.8 (227.9; 1,263.9) pg/ml; p = 0.018] and CCL11 [29.8 (23.5; 54.9) vs. 19.2 (17.8; 29.9) pg/ml; p = 0.041], and sTNF-R1/TNF-α ratio [84.7 (33.2; 124.2) vs. 25.9 (16.3; 75.1); p = 0.012] than HIV-1 ECs with stable CD4+ T-cells. The area under the receiver operating characteristic (ROC) curve [area under ROC curve (AUROC)] were 0.758 ± 0.093 (sTNF-R1), 0.727 ± 0.096 (CCL11), and 0.777 ± 0.087 (sTNF-R1/TNF-α). The cut-off of 75th percentile (high values) for these biomarkers had 71.4% positive predictive value and 73.9% negative predictive value for anticipating the evolution of CD4+ T-cells. In conclusion, the loss of CD4+ T-cells in HIV-ECs was associated with higher levels of two plasma inflammatory biomarkers (sTNF-R1 and CCL11), which were also reasonably accurate for the prediction of the CD4+ T-cells loss. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | |
dc.relation.ispartofseries | Frontiers in Immunology, Volume 9 - 2018 | |
dc.rights | Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional) | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES | |
dc.title | High Plasma levels of sTnF-r1 and ccl11 are related to cD4+ T-cells Fall in human immunodeficiency Virus elite controllers With a sustained Virologic control. | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.3389/fimmu.2018.01399 | |
dc.subject.keyword | human immunodeficiency virus | en |
dc.subject.keyword | elite controllers | en |
dc.subject.keyword | inflammation | en |
dc.subject.keyword | plasma biomarkers | en |
dc.subject.keyword | acquired immune deficiency syndrome | en |
dc.subject.keyword | progression | en |