RT info:eu-repo/semantics/bachelorThesis
T1 Estudio de la Reacción de Suzuki y su aplicación a la síntesis de fármacos
A1 Dias Méndez, María Carolina
K1 Reacción de Suzuki
AB Transition metal catalyzed cross coupling reactions have proven to be one of thesimplest and most widely used forms in Organic Synthesis for carbon-carbon bondformation. In particular, the Suzuki reaction whose purpose is the palladium-catalyzedcross-coupling of boronic acids or derivatives thereof, with alkyl or aryl halides orpseudohalides, has achieved great relevance in research worldwide, especially in thepharmaceutical and chemical industries.The objective of this work is to carry out an updated review of the Suzuki reaction,as well as to deepen its mechanism and scope, and study its usefulness in drugsynthesis.The fact that the Suzuki reaction is so efficient and selective is thanks to thepalladium catalysts. In addition, it should be noted as relevant fact that thesterochemistry present in the coupling alkyl or aryl groups is preserved and that itadmits the presence of various functional groups, which indicates the great versatility ofthe reaction.The application of this reaction has been studied in depth in the synthesis of drugssuch as antihypertensive drugs, anticancer drugs, antibiotics, among others.
YR 2020
FD 2020
LK http://riull.ull.es/xmlui/handle/915/20013
UL http://riull.ull.es/xmlui/handle/915/20013
LA es
DS Repositorio institucional de la Universidad de La Laguna
RD 24-may-2024