RT info:eu-repo/semantics/article
T1 High Plasma levels of sTnF-r1 and ccl11 are related to cD4+ T-cells Fall in human immunodeficiency Virus elite controllers With a sustained Virologic control.
A1 Valenzuela Fernández, Agustín
A1 Gutiérrez Rivas, Mónica
A1 Jiménez Sousa, María Ángeles
A1 Rallón, Norma
A1 Jiménez, José Luis
A1 Restrepo, Clara
A1 León, Agathe
A1 Montero Alonso, Marta
A1 González García, Juan
A1 Muñoz Fernández, María Ángeles
A1 Benito, José Miguel
A1 Resino, Salvador
A2 Medicina Física y Farmacología
A2 Grupo "Inmunología Celular y Viral".
K1 human immunodeficiency virus
K1 elite controllers
K1 inflammation
K1 plasma biomarkers
K1 acquired immune deficiency syndrome
K1 progression
AB Our aim was to analyze the relationship between plasma inflammatory biomarkers andCD4+ T-cells evolution in human immunodeficiency virus (HIV) elite controllers (HIVECs) with a suppressed viremia. We carried out a retrospective study in 30 HIV-ECsclassified into two groups: those showing no significant loss of CD4+ T-cells during theobservation period (stable CD4+, n =  19) and those showing a significant decreaseof CD4+ T-cells (decline CD4+, n = 11). Baseline plasma biomarkers were measuredusing a multiplex immunoassay: sTNF-R1, TRAIL, sFas (APO), sFasL, TNF-α, TNF-β,IL-8, IL-18, IL-6, IL-10, IP-10, MCP-1, MIP-1α, MIP-1β, RANTES, SDF1α, GRO-α, andCCL11. Baseline levels of sTNF-R1 and CCL11 and sTNF-R1/TNF-α ratio correlatedwith the slope of CD4+ T-cells (cells/μl/year) during follow-up [r = −0.370 (p = 0.043),r = −0.314 (p = 0.091), and r = −0.381 (p = 0.038); respectively]. HIV-ECs with decliningCD4+ T-cells had higher baseline plasma levels of sTNF-R1 [1,500.7 (555.7; 2,060.7)pg/ml vs. 450.8 (227.9; 1,263.9) pg/ml; p = 0.018] and CCL11 [29.8 (23.5; 54.9) vs.19.2 (17.8; 29.9) pg/ml; p = 0.041], and sTNF-R1/TNF-α ratio [84.7 (33.2; 124.2) vs.25.9 (16.3; 75.1); p = 0.012] than HIV-1 ECs with stable CD4+ T-cells. The area underthe receiver operating characteristic (ROC) curve [area under ROC curve (AUROC)] were0.758 ± 0.093 (sTNF-R1), 0.727 ± 0.096 (CCL11), and 0.777 ± 0.087 (sTNF-R1/TNF-α).The cut-off of 75th percentile (high values) for these biomarkers had 71.4% positivepredictive value and 73.9% negative predictive value for anticipating the evolution ofCD4+ T-cells. In conclusion, the loss of CD4+ T-cells in HIV-ECs was associated withhigher levels of two plasma inflammatory biomarkers (sTNF-R1 and CCL11), which werealso reasonably accurate for the prediction of the CD4+ T-cells loss.
YR 2018
FD 2018
LK http://riull.ull.es/xmlui/handle/915/35342
UL http://riull.ull.es/xmlui/handle/915/35342
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 06-jun-2024