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dc.contributor.authorPérez, Sixto J.
dc.contributor.authorPurino, Martín A.
dc.contributor.authorCruz, Daniel A.
dc.contributor.authorLópez-Soria, Juan M.
dc.contributor.authorCarballo, Rubén M.
dc.contributor.authorRamírez, Miguel A. 
dc.contributor.authorFernández, Israel
dc.contributor.authorMartín García, Víctor Sotero 
dc.contributor.authorPadrón, Juan I.
dc.date.accessioned2019-09-04T10:36:31Z
dc.date.available2019-09-04T10:36:31Z
dc.date.issued2016
dc.identifier.urihttp://riull.ull.es/xmlui/handle/915/16011
dc.description.abstractA highly efficient diastereoselective iron(III)-catalyzed intramolecular hydroamination/cyclization reaction involving - substituted amino alkenes is described. Thus, enantiopure trans-2,5- disubstituted pyrrolidines and trans-5-substituted proline derivatives are synthesized by means of the combination of enantiopure starting materials, easily available from L--amino acids, with sustainable metal catalysts such as iron(III) salts. The scope of this methodology is highlighted in an enantiodivergent approach to the synthesis of both (+)- and (-)-pyrrolidine 197B alkaloids from L-glutamic acid. In addition, a computational study was also carried out to gain insight into the complete diastereoselectivity of the transformation.es_ES
dc.format.mimetypeapplication/pdf
dc.language.isoenes_ES
dc.publisherWileyes_ES
dc.relation.ispartofseriesChemistry: A European Journal, Vol. 22, n. 43, 2016;
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleEnantiodivergent Synthesis of (+)- and (-)-Pyrrolidine 197B. Synthesis of trans-2,5-Disubstituted Pyrrolidines via Intramolecular Hydroaminationes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.subject.keywordAlcaloideses_ES
dc.subject.keywordciclizaciónes_ES
dc.subject.keywordhidroaminaciónes_ES
dc.subject.keywordaceroes_ES
dc.subject.keywordheterociclos de nitrógenoes_ES
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersiones_ES


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