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dc.contributor.authorMumuni, Momoh A.
dc.contributor.authorCalister, Ugwu E.
dc.contributor.authorAminu, Nafiu
dc.contributor.authorFranklin, Kenechukwu C.
dc.contributor.authorMusiliu, Adedokun O.
dc.contributor.authorUsman, Mohammed
dc.contributor.authorAbdulmumuni, Barikisu
dc.contributor.authorJames, Oyeniyi Y.
dc.contributor.authorOfokansi, Kenneth C.
dc.contributor.authorAnthony, Attama A.
dc.contributor.authorIbezim, Emmanuel C.
dc.contributor.authorDíaz Díaz, David
dc.date.accessioned2020-09-25T08:36:49Z
dc.date.available2020-09-25T08:36:49Z
dc.date.issued2020
dc.identifier.urihttp://riull.ull.es/xmlui/handle/915/21301
dc.description.abstractIn this study, different ratios of mucin-grafted polyethylene-glycol-based microparticles were prepared and evaluated both in vitro and in vivo as carriers for the oral delivery of insulin. Characterization measurements showed that the insulin-loaded microparticles display irregular porosity and shape. The encapsulation efficiency and loading capacity of insulin were >82% and 18%, respectively. The release of insulin varied between 68% and 92% depending on the microparticle formulation. In particular, orally administered insulin-loaded microparticles resulted in a significant fall of blood glucose levels, as compared to insulin solution. Subcutaneous administration showed a faster, albeit not sustained, glucose fall within a short time as compared to the polymeric microparticle-based formulations. These results indicate the possible oral delivery of insulin using this combination of polymers.es_ES
dc.description.sponsorshipTertiary Education Trust Fund (TETFUND)–National Research Fund (NFR)es_ES
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidadeses_ES
dc.language.isoenes_ES
dc.publisherMDPIes_ES
dc.relation.ispartofseriesApplied Sciences, 2020, Vol. 10, N. 8;
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleMucin-Grafted Polyethylene Glycol Microparticles Enable Oral Insulin Delivery for Improving Diabetic Treatmentes_ES
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/app10082649
dc.relation.projectIDTETFUND/DESS/NRF/STI/13/VOL.1es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.subject.keywordinsulines_ES
dc.subject.keywordmucines_ES
dc.subject.keywordpolyethylene glycoles_ES
dc.subject.keywordmicroparticleses_ES
dc.subject.keywordtoxicologyes_ES
dc.subject.keywordinsulinaes_ES
dc.subject.keywordmucinaes_ES
dc.subject.keywordpolietilenglicoles_ES
dc.subject.keywordmicropartículases_ES
dc.subject.keywordtoxicologíaes_ES
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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