Dimorfismo sexual en un modelo de síndrome metabólico

Abstract

The Metabolic Syndrome (MetS) is a group of disorders constituted by obesity of central distribution, dyslipidemia, increase in blood pressure, hyperglycemia and insulin resistance. Since lifestyle and genes are key in its development, in order to avoid MetS it is recommended to combine a healthy lifestyle through a correct diet and aerobic exercise. The serum and glucocorticoid-inducible kinase 1 (SGK1) would be involved in MetS development. This kinase expression is regulated by hormones such as gluco- and mineralocorticoids and, at the transcriptional level, by osmotic and glucose changes. Previous data published by my supervisors have shown as SGK1 overexpression in a model of laboratory mice (B6.Tg.sgk1) is able to reproduce MetS. As there are differences in age and prevalence between sexes in humans, it suggests that sexual hormones may play an important role in MetS causes and/or development, the aims of this project are A) to review the state of the art something to do with the implications of sexual hormones in MetS, B) to elaborate an experimental design in order to research if sexual hormones are able to modify some wellknown parameters related to MetS. To this purpose, we propose to study in two strains of adult laboratory mice (Wild type, WT, and transgenic one overactivated for SGK1, B6.Tg.sgk1) which will be grouped by sexes and fed under a high and low fat diet, respectively, and treated with three different dosage of EMD63863 (inhibitor of SGK1 activity). In order to expanding the level of knowledges on sexual hormones and MetS, we propose a similar pattern design using human as experimental subjects.