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dc.contributor.authorSouto, Ricardo Manuel 
dc.contributor.authorAsserghine, Abdelilah
dc.contributor.authorAshrafi, Amir M.
dc.contributor.authorMukherjee, Atripan
dc.contributor.authorPetrlak, Frantisek
dc.contributor.authorHeger, Zbynek
dc.contributor.authorSvec, Pavel
dc.contributor.authorRichtera, Lukas
dc.contributor.authorNagy, Lívia
dc.contributor.authorNagy, Géza
dc.contributor.authorAdam, Vojtech
dc.contributor.otherQuímica
dc.contributor.otherDepartamento de Química Grupo de Electroquímica y Corrosión Instituto de Materiales y Nanotecnología
dc.date2021
dc.date.accessioned2021-09-15T19:55:26Z
dc.date.available2021-09-15T19:55:26Z
dc.identifier.urihttp://riull.ull.es/xmlui/handle/915/25284
dc.description.abstractRecently, the cytotoxic properties of galvanically coupled Mg-Ti particles have been shown to different cells, although this cytotoxic effect has been attributed mainly to Mg due to its tendency to undergo activation when coupled with Ti forming a galvanic cell consisting of an anode (Mg) and a cathode (Ti). However, the role of the Ti cathode has been ignored in explaining the cytotoxic effect of Mg-Ti particles due to its high resistance to corrosion. In this work, the role of titanium (Ti) in the cytotoxic mechanism of galvanically coupled Mg-Ti particles was examined. A model galvanic cell was prepared to simulate the Mg-Ti particles. The electrochemical reactivity of the Ti sample and the pH change above it due to galvanic coupling with Mg were investigated using scanning electrochemical microscopy (SECM). It was observed that the Ti surface changed from passive to electrochemically active when coupled with Mg. Furthermore, after only 15 min galvanic coupling with Mg, the pH in the electrolyte volume adjacent to the Ti surface increased to an alkaline pH value. The effects of the galvanic coupling of Ti and Mg, as well as of the alkaline pH environment, on the viability of Hs27 fibroblast cells were investigated. It was shown that the viability of Hs27 cells significantly diminished when Mg and Ti were galvanically coupled compared to when the two metals were electrically disconnected. Next, the generation of reactive oxygen species (ROS) increased when the Ti and Mg were galvanically coupled. Thus, although Ti usually exhibited high corrosion resistance when exposed to physiological environments, an electrochemically active surface was observed when galvanically coupled with Mg, and this surface may participate in electron transfer reactions with chemical species in the neighboring environment; this participation resulted in the increased pH values above its surface and enhanced generation of ROS. These features contributed to the development of cytotoxic effects by galvanically coupled Mg-Ti particles.en
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.relation.ispartofseriesACS Applied Materials & Interfaces 13 (2021)en
dc.rightsLicencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES
dc.titleIn situ investigation of the cytotoxic and interfacial characteristics of titanium when galvanically coupled with magnesium using scanning electrochemical microscopyen
dc.identifier.doi10.1021/acsami.2021.1c10584
dc.subject.keywordtitaniumen
dc.subject.keywordmagnesiumen
dc.subject.keywordgalvanic couplingen
dc.subject.keywordlocal electrochemical activityen
dc.subject.keywordcytotoxic effectsen
dc.subject.keywordpH variationsen
dc.subject.keywordreactive oxygen speciesen


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Except where otherwise noted, this item's license is described as Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)