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dc.contributor.authorCastro Hernández, Javier 
dc.contributor.authorArmas González, Estefanía
dc.contributor.authorDomínguez Luis, María Jesús
dc.contributor.authorDíaz Martín, Ana
dc.contributor.authorArce Franco, Mayte
dc.contributor.authorDanelon, Gabriela
dc.contributor.authorHernández Hernández, Vanesa
dc.contributor.authorBustabad Reyes, Sagrario 
dc.contributor.authorCantabrana, Alberto
dc.contributor.authorUguccioni, Mariagrazia
dc.contributor.authorDíaz González, José Federico 
dc.contributor.otherMedicina Física y Farmacología
dc.date.accessioned2023-12-13T21:09:29Z
dc.date.available2023-12-13T21:09:29Z
dc.date.issued2018
dc.identifier.urihttp://riull.ull.es/xmlui/handle/915/34778
dc.description.abstractBackground: B cells exert their pathogenic action in rheumatoid arthritis (RA) locally in the synovium. This study was undertaken to elucidate the chemokines responsible for the recruitment of B cells in the inflamed synovium, taking into account that the rich chemokine milieu present in the synovial tissue can fine-tune modulate discrete chemokine receptors. Methods: Expression levels of chemokine receptors from the CC and CXC family, as well as CD27, were assessed by flow cytometry in CD20+ mononuclear cells isolated from the peripheral blood (PB) and synovial fluid (SF) of RA and psoriatic arthritis patients. Transwell experiments were used to study migration of B cells in response to a chemokine or in the presence of multiple chemokines. Results: B cells from the SF of arthritis patients showed a significant increase in the surface expression of CCR1, CCR2, CCR4, CCR5 and CXCR4 with respect to PB. Conversely, SF B cells expressed consistently lower amounts of CXCR5, CXCR7 and CCR6, independent of CD27 expression. Analysis of permeabilized B cells suggested internalization of CXCR5 and CCR6 in SF B cells. In Transwell experiments, CCL20 and CXCL13, ligands of CCR6 and CXCR5, respectively, caused a significantly higher migration of B cells from PB than of those from SF of RA patients. Together, these two chemokines synergistically increased B-cell migration from PB, but not from SF. Conclusions: These results suggest that CXCL13 and CCL20 might play major roles in RA pathogenesis by acting singly on their selective receptors and synergistically in the accumulation of B cells within the inflamed synovium.en
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.relation.ispartofseriesArthritis Research and Therapy, 20, 114 (2018)
dc.rightsLicencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES
dc.titleRole of CXCL13 and CCL20 in the recruitment of B cells to inflammatory foci in chronic arthritisen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1186/s13075-018-1611-2
dc.subject.keywordRheumatoid arthritisen
dc.subject.keywordPsoriatic arthritisen
dc.subject.keywordB cellsen
dc.subject.keywordChemokines and chemokine receptorsen


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