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dc.contributor.authorArias Rodríguez, María De Los Ángeles
dc.contributor.authorCallejón Fernández, Manuel
dc.contributor.authorAbreu Rodríguez, Rossana
dc.contributor.authorArias, Ángeles 
dc.contributor.authorAguirre-Jaime, Armando
dc.contributor.authorCastro Hernández, María Beatriz
dc.contributor.authorRamos Real, María José
dc.contributor.authorPedroso Fernández, Yanet
dc.contributor.authorLecuona, María
dc.date.accessioned2023-12-15T21:05:56Z
dc.date.available2023-12-15T21:05:56Z
dc.date.issued2023
dc.identifier.issn2076-2607
dc.identifier.urihttp://riull.ull.es/xmlui/handle/915/34820
dc.description.abstractMethicillin-resistant Staphylococcus aureus (MRSA) colonization has been considered a risk factor for the development of infection, however, there are no studies that have compared the colonizing and infecting strains using whole-genome sequencing (WGS). The aim of this study is to determine the prevalence of and risk factors for MRSA colonization among long-term care facilities (LTCF) residents of Tenerife (Spain), and to analyze the epidemiological relationship between the colonizing and infecting strains using WGS. A point-prevalence study was carried out at 14 LTCFs in Tenerife from October 2020 to May 2021. Nasal swabs were cultured for MRSA. Colonized residents were followed up for two years. A phylogenetic comparison between colonization and infection strains was performed using WGS. A total of 764 residents were included. The prevalence of colonization by MRSA was 28.1% (n = 215), of which 12 (5.6%) subsequently developed infection. A close genetic relationship between colonization and infection isolates was found in three of the four (75%) residents studied. Our study confirms that colonized residents can develop serious MRSA infections from the same nasal colonization strain. Given the high prevalence of MRSA colonization in these centers, it is necessary to implement strategies with preventive measures to avoid the development of infection and the transmission of MRSA.
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.relation.ispartofseriesMicroorganisms 2023, 11, 2842
dc.rightsLicencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES
dc.titleThe Impact of MRSA Colonization on Healthcare-Associated Infections in Long-Term Care Facility Residents: A Whole-Genome Sequencing-Based Study
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/microorganisms11122842
dc.subject.keywordMRSA
dc.subject.keywordlong-term care facilities
dc.subject.keywordcolonization
dc.subject.keywordinfection
dc.subject.keywordprevalence
dc.subject.keywordwhole-genome sequencing


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Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
Except where otherwise noted, this item's license is described as Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)