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dc.contributor.authorBarrios del Pino, Yvelise 
dc.contributor.authorPlaza, A.
dc.contributor.authorCabrera, R.
dc.contributor.authorDíaz Espada, F.
dc.date.accessioned2023-12-19T21:07:40Z
dc.date.available2023-12-19T21:07:40Z
dc.date.issued2000
dc.identifier.issn0903-4641
dc.identifier.urihttp://riull.ull.es/xmlui/handle/915/34905
dc.description.abstractIn patients with B-cell lymphoma, only in rare cases a secreted paraprotein is found, and in very few of them an associated autoantibody activity has been demonstrated. Here we report the case of a patient with a low-grade B-cell lymphoma with a serum biclonal paraprotein (G,M)l and severe erythroblastopenia. Indirect immunofluorescence studies of total serum revealed cytoplasmic (Hep-2 cells) and extracellular matrix (rat tissue sections) staining, suggestive of a new specificity. After gel filtration of serum samples, only the IgM-containing fraction showed the same pattern of staining. Tumor-derived hybridomas expressed an unmutated V3–11 gene identical to that found in tumor samples and secreted an IgM immunoglobulin endowed with the same reactivity, which confirms the tumoral origin of the tissue-reactive protein. The results suggest a link between the autoimmune condition in this patient and the novel specificity displayed by the tumor-derived immunoglobulin.en
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.relation.ispartofseriesAPMIS 108: 764-70, 2000
dc.rightsLicencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES
dc.titleAutoantibody activity of the immunoglobulin secreted by a follicular B-cell lymphoma
dc.typeinfo:eu-repo/semantics/article
dc.subject.keywordBiclonal lymphoma
dc.subject.keywordAutoantibodies
dc.subject.keywordVH-genes


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Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
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