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A novel application of delayed-type hipersensitivity reaction to measure cellular immune response in SARS-CoV-2 exposed individuals.
| dc.contributor.author | Barrios del Pino, Yvelise | |
| dc.contributor.author | Franco, Andrés | |
| dc.contributor.author | Sánchez Machín, Inmaculada | |
| dc.contributor.author | Poza Guedes, Paloma | |
| dc.contributor.author | González Pérez, Ruperto | |
| dc.contributor.author | Matheu, Victor | |
| dc.contributor.other | Medicina Interna, Dermatología y Psiquiatría | |
| dc.contributor.other | Hospital Universitario de Canarias | |
| dc.date.accessioned | 2023-12-19T21:08:28Z | |
| dc.date.available | 2023-12-19T21:08:28Z | |
| dc.date.issued | 2021 | |
| dc.identifier.uri | http://riull.ull.es/xmlui/handle/915/34913 | |
| dc.description.abstract | Objective: To understand the anti-virus adaptive immune response occurring during SARS-Cov-2 infection is necessary to have methods to investigate cellular and humoral components. The goal of this study has been to investigate the utility of a specific spike-DTH test using a coronavirus recombinant protein in COVID-19 patients. Methods: DTH studies were performed by intradermal injection of a commercial recombinant spike protein from SARS-CoV-2 along with conventional serology studies. Results: Fifty-one COVID-19 patients were studied showing 84,3% of concordance with spike-DTH and anti-RBDIgG. Spike-DTH was superior to identify seven more COVID-19 individuals. A high specificity was found with no positive spike DTH reactions in the non-sick individuals. The skin test also showed more stable results over time while specific anti-RBD-IgG decreased gradually. Clinical severity groups also showed a progressive gradient of larger positive spike-DTH. Conclusion: Specific spike DTH test seems to be an easy method to study cell immune response | en |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | Clinical Immunology, Volume 226, May 2021, 108730 | |
| dc.rights | Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional) | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES | |
| dc.title | A novel application of delayed-type hipersensitivity reaction to measure cellular immune response in SARS-CoV-2 exposed individuals. | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | 10.1016/j.clim.2021.108730 | |
| dc.subject.keyword | SARS-cov2 | en |
| dc.subject.keyword | DTH | en |
| dc.subject.keyword | Skin test | en |
| dc.subject.keyword | Delayed-type hypersensitivity | en |
| dc.subject.keyword | T-cell response | en |
| dc.subject.keyword | COVID-19 | en |
| dc.subject.keyword | Cell response | en |
| dc.subject.keyword | Humoral response | en |
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DMIPS. Medicina Interna, Dermatología y Psiquiatría
Documentos de investigación (artículos, libros, capítulos de libros, ponencias...) publicados por investigadores del Departamento de Medicina Interna, Dermatología y Psiquiatría
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