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Length of the antibody heavy chain complementarity determining region 3 as a specificity-determining factor
| dc.contributor.author | Barrios del Pino, Yvelise | |
| dc.contributor.author | Jirholtz, Pernilla | |
| dc.contributor.author | Ohlin, Mats | |
| dc.date.accessioned | 2023-12-19T21:08:35Z | |
| dc.date.available | 2023-12-19T21:08:35Z | |
| dc.date.issued | 2004 | |
| dc.identifier.issn | 0952-3499 | |
| dc.identifier.uri | http://riull.ull.es/xmlui/handle/915/34914 | |
| dc.description.abstract | Theantigenbindingsiteofanantibodyismadeupofresiduesresidinginsixhypervariableloopsof the heavyandlightchains.Inmostcasesseveraloralloftheseloopsarerequiredfortheestablishmentofthe antigen-bindingsurface.Fiveoftheseloopsdisplayalimiteddiversityinlengthandsequencewhilethethird complementaritydeterminingregion(CDR)oftheheavychainishighlydifferentbetweenantibodiesnot onlywithrespecttosequencebutalsowithrespecttolength.Itsextensivediversityisakeycomponentinthe establishmentofbindingsitesallowingfortherecognitionofessentiallyanyantigenbyhumoralimmunity. Therelative importanceof its sequencevs its lengthdiversity inthiscontext ishowever, notverywell established.Toinvestigatethismatterfurtherwehaveusedanapproachemployingcombinatorialantibody librariesandantigen-specificselectioninthesearchforCDRH3lengthandsequencediversitycompatible withagivenantigenspecificity,themajorantigenicdeterminantonthetumour-associatedantigenmucin-1. InthiswaywehavenowdefinedheavychainCDR3lengthasacriticalparameterinthecreationofan antigen-specificbindingsite.Wealsoproposethatthismayreflectadependenceofaparticularstructureof thishypervariable loop, themajorcarrierofdiversity inthebindingsite, forestablishmentofagiven specificity | en |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | en | |
| dc.relation.ispartofseries | J. Mol. Recognit. 2004, 17:332–338 | |
| dc.rights | Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional) | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES | |
| dc.title | Length of the antibody heavy chain complementarity determining region 3 as a specificity-determining factor | |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | 10.1002/jmr.679 | |
| dc.subject.keyword | Antibody | |
| dc.subject.keyword | Antigen | |
| dc.subject.keyword | Complementarity determining region | |
| dc.subject.keyword | Diversity | |
| dc.subject.keyword | Loop | |
| dc.subject.keyword | Specificity |
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Documentos de investigación (artículos, libros, capítulos de libros, ponencias...) publicados por investigadores del Departamento de Medicina Interna, Dermatología y Psiquiatría
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