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dc.contributor.authorGonzález Gómez, Miriam 
dc.contributor.authorDíaz Flores, Lucio
dc.contributor.authorGutiérrez, Ricardo
dc.contributor.authorGarcía, María del Pino
dc.contributor.authorDíaz-Flores, Lucio Jr
dc.contributor.authorGonzález-Marrero, Ibrahim
dc.contributor.authorÁvila, Julio
dc.contributor.authorMartín Vasallo, Pablo 
dc.date.accessioned2023-12-23T21:06:36Z
dc.date.available2023-12-23T21:06:36Z
dc.date.issued2021
dc.identifier.issn2073-4409
dc.identifier.urihttp://riull.ull.es/xmlui/handle/915/35014
dc.description.abstract: Glioblastoma (GBM) is the most malignant tumor in the brain. In addition to the vascular pattern with thin-walled vessels and findings of sprouting angiogenesis, GBM presents a bizarre microvasculature (BM) formed by vascular clusters, vascular garlands, and glomeruloid bodies. The mechanisms in BM morphogenesis are not well known. Our objective was to assess the role of pericyte/endothelial proliferation and intussusceptive angiogenic mechanisms in the formation of the BM. For this purpose, we studied specimens of 66 GBM cases using immunochemistry and confocal microscopy. In the BM, the results showed (a) transitional forms between the BM patterns, mostly with prominent pericytes covering all the abluminal endothelial cell (EC) surface of the vessels, (b) a proliferation index high in the prominent pericytes and low in ECs (47.85 times higher in pericytes than in ECs), (c) intravascular pillars (hallmark of intussusceptive angiogenesis) formed by transcapillary interendothelial bridges, endothelial contacts of opposite vessel walls, and vessel loops, and (d) the persistence of these findings in complex glomeruloid bodies. In conclusion, disproportion in pericyte/EC proliferation and mechanisms of intussusceptive angiogenesis participate in BM formation. The contributions have morphogenic and clinical interest since pericytes and intussusceptive angiogenesis can condition antiangiogenic therapy in GBM.en
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.relation.ispartofseriesCells 2021, 10 (10)
dc.rightsLicencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES
dc.titleDisproportion in pericyte/endothelial cell proliferation and mechanisms of intussusceptive angiogenesis participate in bizarre vessel formation in glioblastoma
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/cells10102625
dc.subject.keywordglioblastoma
dc.subject.keywordpericytes
dc.subject.keywordendothelial cells
dc.subject.keywordintussusceptive angiogenesis
dc.subject.keywordbizarre/aberrant microvasculature
dc.subject.keywordglomeruloid bodies
dc.subject.keywordproliferation index


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