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dc.contributor.authorGonzález Gómez, Miriam 
dc.contributor.authorDíaz‐flores, Lucio
dc.contributor.authorGutiérrez, Ricardo
dc.contributor.authorGarcía, María Pino
dc.contributor.authorCarrasco, José Luís
dc.contributor.authorMartín‐Vasallo, Pablo
dc.contributor.otherCiencias Médicas Básicas
dc.contributor.otherGrupo de investigación: Neurobiología Humana.
dc.date.accessioned2023-12-23T21:07:34Z
dc.date.available2023-12-23T21:07:34Z
dc.date.issued2021
dc.identifier.issn1422-0067
dc.identifier.urihttp://riull.ull.es/xmlui/handle/915/35025
dc.descriptionInt J Mol Sci. 2021 Apr 1;22(7):3686. doi: 10.3390/ijms22073686. PMID: 33916213; PMCID: PMC8037555. Autores: Díaz-Flores L, Gutiérrez R, González-Gómez M, García MP, Díaz-Flores L Jr, Carrasco JL, Martín-Vasallo P.
dc.description.abstractSeveral origins have been proposed for cancer‐associated fibroblasts (CAFs), including resident CD34+ stromal cells/telocytes (CD34+SCs/TCs). The characteristics and arrangement of mammary CD34+SCs/TCs are well known and invasive lobular carcinoma of the breast (ILC) is one of the few malignant epithelial tumours with stromal cells that can express CD34 or αSMA, which could facilitate tracking these cells. Our objective is to assess whether tissue‐resident CD34+SCs/TCs participate in the origin of CAFs in ILCs. For this purpose, using conventional and immunohisto-chemical procedures, we studied stromal cells in ILCs (n:42) and in normal breasts (n:6, also using electron microscopy). The results showed (a) the presence of anti‐CD34+ or anti‐αSMA+ stromal cells in varying proportion (from very rare in one of the markers to balanced) around nests/strands of neoplastic cells, (b) a similar arrangement and location of stromal cells in ILC to CD34+SCs/TCs in the normal breast, (c) both types of stromal cells coinciding around the same nest of neoplastic cells and (d) the coexpression of CD34 and αSMA in stromal cells in ILC. In conclusion, our findings support the hypothesis that resident CD34+SCs/TCs participate as an important source of CAFs in ILC. Further studies are required in this regard in other tumours.
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.relation.ispartofseriesInternational Journal of Molecular Sciences 22, n.º 7 (2021)
dc.rightsLicencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES
dc.titleCD34+ Stromal Cells/Telocytes as a Source of Cancer-Associated Fibroblasts (CAFs) in Invasive Lobular Carcinoma of the Breast.
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doihttps://doi.org/10.3390/IJMS22073686
dc.subject.keywordTelocytes
dc.subject.keywordCancer-associated fibroblasts
dc.subject.keywordCAFs
dc.subject.keywordInvasive lobular carcinoma
dc.subject.keywordBreast


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