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dc.contributor.authorAfonso Oramas, Domingo 
dc.contributor.authorSantana Cordón, Laura
dc.contributor.authorLemus Mesa, Alejandro
dc.contributor.authorTeixidó Trujillo, Silvia
dc.contributor.authorRodríguez Rodríguez, Ana Elena 
dc.contributor.authorCruz Muros, Ignacio de la
dc.contributor.authorGonzález Gómez, Miriam 
dc.contributor.authorBarroso Chinea, Pedro 
dc.date.accessioned2023-12-23T21:07:40Z
dc.date.available2023-12-23T21:07:40Z
dc.date.issued2023
dc.identifier.issn1873-2747
dc.identifier.issn0361-9230
dc.identifier.urihttp://riull.ull.es/xmlui/handle/915/35026
dc.description.abstractThe suprachiasmatic nucleus (SCN) is the main region for the regulation of circadian rhythms. Although the SCN contains a heterogeneous neurochemical phenotype with a wide variety of neuropeptides, a key role has been suggested for the vasoactive intestinal neuropeptide (VIP) as a modulator circadian, reproductive, and seasonal rhythms. VIP is a 28-amino acid polypeptide hormone that belongs to the secretin-glucagon peptide superfamily and shares 68 % homology with the pituitary adenylate cyclase-activating polypeptide (PACAP). VIP acts as an endogenous appetite inhibitor in the central nervous system, where it participates in the control of appetite and energy homeostasis. In recent years, significant efforts have been made to better understand the role of VIP in the regulation of appetite/satiety and energy balance. This study aimed to elucidate the long-term effect of an obesogenic diet on the distribution and expression pattern of VIP in the SCN and nucleus accumbens (NAc) of C57BL/6 mice. A total of 15 female C57BL/6J mice were used in this study. Female mice were fed ad libitum with water and, either a standard diet (SD) or a high-fat diet (HFD) to induce obesity. There were 7 female mice on the SD and 8 on the HFD. The duration of the experiment was 365 days. The morphological study was performed using immunohistochemistry and double immunofluorescence techniques to study the neurochemical profile of VIP neurons of the SCN of C57BL/6 mice. Our data show that HFD-fed mice gained weight and showed reduced VIP expression in neurons of the SCN and also in fibres located in the NAc. Moreover, we observed a loss of neuropeptide Y (NPY) expression in fibres surrounding the SCN. Our findings on VIP may contribute to the understanding of the pathophysiological mechanisms underlying obesity in regions associated with uncontrolled intake of high-fat foods and the reward system, thus facilitating the identification of novel therapeutic targets.en
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.relation.ispartofseriesBrain Research Bulletin, 2023 nº 202
dc.rightsLicencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES
dc.titleDrastic decline in vasoactive intestinal peptide expression in the suprachiasmatic nucleus in obese mice on a long-term high-fat diet.
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.brainresbull.2023.110756
dc.subject.keywordSuprachiasmatic nucleusen
dc.subject.keywordNucleus accumbensen
dc.subject.keywordVasoactive intestinal peptideen
dc.subject.keywordNeuropeptide y obesityen
dc.subject.keywordHigh-fat dieten


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Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
Except where otherwise noted, this item's license is described as Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)