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dc.contributor.authorGonzález Gómez, Miriam 
dc.contributor.authorDíaz Flores , Lucio
dc.contributor.authorGutiérrez, Ricardo
dc.contributor.authorGarcía, Mª Pino
dc.contributor.authorGayoso, Sara
dc.contributor.authorCarrasco, José Luis
dc.contributor.authorDíaz Flores, Lucio Jr.
dc.contributor.authorGonzález Gómez, Miriam
dc.contributor.authorMadrid, Juan Francisco
dc.date.accessioned2023-12-23T21:07:45Z
dc.date.available2023-12-23T21:07:45Z
dc.date.issued2020
dc.identifier.urihttp://riull.ull.es/xmlui/handle/915/35027
dc.descriptionInt J Mol Sci. 2020 Oct 28;21(21):8049. doi: 10.3390/ijms21218049. PMID: 33126763; PMCID: PMC7663623. Autores: Díaz-Flores L, Gutiérrez R, García MP, Gayoso S, Carrasco JL, Díaz-Flores L Jr, González-Gómez M, Madrid JF.
dc.description.abstractAngiogenesis in arterial intimal thickening (AIT) has been considered mainly in late AIT stages and only refers to sprouting angiogenesis. We assess angiogenesis during early AIT development and the occurrence of the intussusceptive type. For this purpose, we studied AIT development in (a) human arteries with vasculitis in gallbladders with acute cholecystitis and urgent (n = 25) or delayed (n = 20) cholecystectomy, using immunohistochemical techniques and (b) experimentally occluded arterial segments (n = 56), using semithin and ultrathin sections and electron microscopy. The results showed transitory angiogenic phenomena, with formation of an important microvasculature, followed by vessel regression. In addition to the sequential description of angiogenic and regressive findings, we mainly contribute (a) formation of intravascular pillars (hallmarks of intussusception) during angiogenesis and vessel regression and (b) morphological interrelation between endothelial cells (ECs) in the arterial wall and vascular smooth muscle cells (VSMCs), which adopt a pericytic arrangement and establish peg-and-socket junctions with ECs. In conclusion, angiogenesis and vessel regression play an important role in AIT development in the conditions studied, with participation of intussusceptive angiogenesis during the formation and regression of a provisional microvasculature and with morphologic interrelation between ECs and VSMCs.en
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.relation.ispartofseriesInternational Journal of Molecular Sciences, 2020, 21(21), 8049
dc.rightsLicencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES
dc.titleIntussusceptive angiogenesis and peg-socket junctions between endothelial cells and smooth muscle cells in early arterial intimal thickening
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/ijms21218049
dc.subject.keywordArterial intimal thickeningen
dc.subject.keywordAngiogenesisen
dc.subject.keywordIntussusceptive angiogenesisen
dc.subject.keywordPeg-and-socket junctionsen
dc.subject.keywordVascular regressionen
dc.subject.keywordEndothelial cellsen
dc.subject.keywordVascular smooth muscle cellsen
dc.subject.keywordPlateletsen


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Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
Except where otherwise noted, this item's license is described as Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)