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dc.contributor.authorValenzuela Fernández, Agustín 
dc.contributor.authorCiuffreda, Laura
dc.contributor.authorLorenzo Salazar, José M.
dc.contributor.authorAlcoba Florez, Julia
dc.contributor.authorRodriguez Pérez, Héctor
dc.contributor.authorGil Campesino, Helena
dc.contributor.authorHayek Peraza, Marcelino
dc.contributor.authorRojo Alba, Susana
dc.contributor.authorÁlvarez Argüelles, Marta Elena
dc.contributor.authorDíez Gil, Óscar
dc.contributor.authorGonzález Montelongo, Rafaela
dc.contributor.authorFlores, Carlos
dc.contributor.otherMedicina Física y Farmacología
dc.contributor.otherGrupo "inmunología Celular y Viral".
dc.date.accessioned2024-01-15T21:07:08Z
dc.date.available2024-01-15T21:07:08Z
dc.date.issued2021
dc.identifier.urihttp://riull.ull.es/xmlui/handle/915/35336
dc.descriptionPreprint Research Square. DOI: https://doi.org/10.21203/rs.3.rs-702594/v2 License: ¿ ¿ This work is licensed under a Creative Commons Attribution 4.0 International License.
dc.description.abstractWe describe the case of a 23-year-old immunocompromised male patient with clinically diagnosed Xlinked agammaglobulinemia who was admitted to the hospital on the 14th April 2020 due to coronavirus disease of 2019 (COVID-19). Despite COVID-19 test negativizations, the patient was hospitalized most of the time and finally admitted to the intensive care unit where he died from multiorgan failure and shock. Over 149 days, 26 respiratory samples were collected, subjected to viral genome sequencing, and all assigned to the same lineage, supporting a single viral infection event. The accumulation of mutations throughout the course of the infection was accelerated and suggested the presence of compartmentalized viral subpopulations that evolved independently in the upper and lower respiratory airways. These results support that long-term viral shedding in immunocompromised patients is one possible mechanism for the emergence of variants of concern and provide evidence towards the infection control guidelines in these patients.en
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.rightsLicencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES
dc.titleLongitudinal study of a SARS-CoV-2 infection in an immunocompromised patient with X-linked agammaglobulinemia.en
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.jinf.2021.07.028
dc.subject.keywordImmunocompromised patienten
dc.subject.keywordlong-term viral sheddingen
dc.subject.keywordSARS-CoV-2en
dc.subject.keywordCOVID-19en
dc.subject.keywordviral variantsen


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