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dc.contributor.authorPérez Pérez, José Antonio
dc.contributor.authorMarrero, Manuel
dc.contributor.authorMonroig, Óscar
dc.contributor.authorBetancor, Mónica
dc.contributor.authorHerrera, Marcelino
dc.contributor.authorGarrido, Diego 
dc.contributor.authorGalindo, Ana
dc.contributor.authorGiráldez, Inmaculada
dc.contributor.authorRodríguez, Covadonga
dc.contributor.otherBiología Animal y Edafología y Geología
dc.contributor.otherGrupo de investigación NUTRAHLIPIDS (Fisiología de los Lípidos y sus Derivados en la Alimentación Animal y Humana)
dc.date.accessioned2024-01-17T21:05:46Z
dc.date.available2024-01-17T21:05:46Z
dc.date.issued2021
dc.identifier.urihttp://riull.ull.es/xmlui/handle/915/35418
dc.descriptionhttps://doi.org/10.3390/md19050254
dc.description.abstractFish vary in their ability to biosynthesise long-chain polyunsaturated fatty acids (LC-PUFA) depending upon the complement and function of key enzymes commonly known as fatty acyl desaturases and elongases. It has been reported in Solea senegalensis the existence of a ∆4 desaturase, enabling the biosynthesis of docosahexaenoic acid (DHA) from eicosapentaenoic acid (EPA), which can be modulated by the diet. The present study aims to evaluate the combined effects of the partial replacement of fish oil (FO) with vegetable oils and reduced environmental salinity in the fatty acid composition of relevant body compartments (muscle, hepatocytes and enterocytes), the enzymatic activity over α-linolenic acid (ALA) to form n-3 LC-PUFA through the incubation of isolated hepatocytes and enterocytes with [1-14C] 18:3 n-3, and the regulation of the S. senegalensis fads2 and elovl5 in the liver and intestine. The presence of radiolabelled products, including 18:4n-3, 20:4n-3 and EPA, provided compelling evidence that a complete pathway enabling the biosynthesis of EPA from ALA, establishing S. senegalensis, has at least one Fads2 with ∆6 activity. Dietary composition prevailed over salinity in regulating the expression of fads2, while salinity did so over dietary composition for elovl5. FO replacement enhanced the proportion of DHA in S. senegalensis muscle and the combination with 20 ppt salinity increased the amount of n-3 LC-PUFA in hepatocytes.en
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.relation.ispartofseriesMarine Drugs 2021, 19, 254
dc.rightsLicencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES
dc.titleInfluence of dietary lipids and environmental salinity on the n-3 long-chain polyunsaturated fatty acids biosynthesis capacity of the marine teleost Solea senegalensisen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/md19050254
dc.subject.keywordSolea senegalensisen
dc.subject.keywordFads2en
dc.subject.keywordElovl5en
dc.subject.keywordLC-PUFA biosynthesisen
dc.subject.keyworddieten
dc.subject.keywordsalinityen
dc.subject.keywordEPAen
dc.subject.keywordDHAen


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