Show simple item record

dc.contributor.authorAcebes Vindel, Ángel José 
dc.contributor.authorGuebel, Daniel V. 
dc.contributor.authorTorres, Néstor V.
dc.date.accessioned2024-01-29T21:05:53Z
dc.date.available2024-01-29T21:05:53Z
dc.date.issued2021
dc.identifier.urihttp://riull.ull.es/xmlui/handle/915/35807
dc.description.abstractCompromise of the vascular system has important consequences on cognitive abilities and neurodegeneration. The identification of the main molecular signatures present in the blood vessels of human hippocampus could provide the basis to understand and tackle these pathologies. As direct vascular experimentation in hippocampus is problematic, we achieved this information by computationally disaggregating publicly available whole microarrays data of human hippocampal homogenates. Three conditions were analyzed: ‘Young Adults’, ‘Aged’, and ‘aged with Mild Cognitive Impairment’ (MCI). The genes identified were contrasted against two independent data-sets. Here we show that the endothelial cells from the Younger Group appeared in an ‘activated stage’. In turn, in the Aged Group, the endothelial cells showed a significant loss of response to shear stress, changes in cell adhesion molecules, increased inflammation, brain-insulin resistance, lipidic alterations, and changes in the extracellular matrix. Some specific changes in the MCI group were also detected. Noticeably, in this study the features arisen from the Aged Group (high tortuosity, increased bifurcations, and smooth muscle proliferation), pose the need for further experimental verification to discern between the occurrence of arteriogenesis and/or vascular remodeling by capillary arterialization.en
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.relation.ispartofseriesThe Company of Biologists (2021)
dc.rightsLicencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES
dc.titleMapping the transcriptomic changes of endothelial compartment in human hippocampus across aging and mild cognitive impairment.
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1242/bio.057950
dc.subject.keywordVascular remodeling
dc.subject.keywordSprouting angiogenesis,
dc.subject.keywordAtherosclerosis
dc.subject.keywordVascular inflammation
dc.subject.keywordCapillary arterialization
dc.subject.keywordSplice forms
dc.subject.keywordMicroarray


Files in this item

This item appears in the following Collection(s)

Show simple item record

Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
Except where otherwise noted, this item's license is described as Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)