dc.contributor.author | Acebes Vindel, Ángel José | |
dc.contributor.author | Guebel, Daniel V. | |
dc.contributor.author | Torres, Néstor V. | |
dc.date.accessioned | 2024-01-29T21:05:53Z | |
dc.date.available | 2024-01-29T21:05:53Z | |
dc.date.issued | 2021 | |
dc.identifier.uri | http://riull.ull.es/xmlui/handle/915/35807 | |
dc.description.abstract | Compromise of the vascular system has important consequences on
cognitive abilities and neurodegeneration. The identification of the
main molecular signatures present in the blood vessels of human
hippocampus could provide the basis to understand and tackle these
pathologies. As direct vascular experimentation in hippocampus is
problematic, we achieved this information by computationally
disaggregating publicly available whole microarrays data of human
hippocampal homogenates. Three conditions were analyzed: ‘Young
Adults’, ‘Aged’, and ‘aged with Mild Cognitive Impairment’ (MCI). The
genes identified were contrasted against two independent data-sets.
Here we show that the endothelial cells from the Younger Group
appeared in an ‘activated stage’. In turn, in the Aged Group, the
endothelial cells showed a significant loss of response to shear
stress, changes in cell adhesion molecules, increased inflammation,
brain-insulin resistance, lipidic alterations, and changes in the
extracellular matrix. Some specific changes in the MCI group were
also detected. Noticeably, in this study the features arisen from the
Aged Group (high tortuosity, increased bifurcations, and smooth
muscle proliferation), pose the need for further experimental
verification to discern between the occurrence of arteriogenesis
and/or vascular remodeling by capillary arterialization. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | |
dc.relation.ispartofseries | The Company of Biologists (2021) | |
dc.rights | Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional) | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES | |
dc.title | Mapping the transcriptomic changes of endothelial compartment in human hippocampus across aging and mild cognitive impairment. | |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1242/bio.057950 | |
dc.subject.keyword | Vascular remodeling | |
dc.subject.keyword | Sprouting angiogenesis, | |
dc.subject.keyword | Atherosclerosis | |
dc.subject.keyword | Vascular inflammation | |
dc.subject.keyword | Capillary arterialization | |
dc.subject.keyword | Splice forms | |
dc.subject.keyword | Microarray | |