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dc.contributor.authorLeón Guerra, Leandro Jesús
dc.contributor.authorLópez, Manuel R.
dc.contributor.authorMoujir, Laila
dc.date.accessioned2024-01-30T21:06:26Z
dc.date.available2024-01-30T21:06:26Z
dc.date.issued2011
dc.identifier.urihttp://riull.ull.es/xmlui/handle/915/35853
dc.description.abstractTwo phenolic triterpenoids, pristimerol (30 µg/mL) and 8-epi-6- deoxoblepharodol (20 µg/mL), obtained by catalytic reduction of pristimerin, exhibited bacteriostatic action against Staphylococcus epidermidis. This activity was not dependent on the inoculum size and the growth phase although it showed a stronger effect when cells were growing actively. Addition of phenolic triterpenoids to S. epidermidis cultures in the log-phase of growth led to an inhibitory effect on incorporation and uptake of radiolabeled precursors thymidine, uridine, leucine, and N-acetyl-glucosamine after 30 min of treatment. Furthermore, a clear release of UV-absorbing material and leakage of intracellular potassium were also detected. These findings, coupled with the high lipophilicity of these molecules, shown by high ClogP values, suggest that 8-epi and pristimerol are able to interact within the lipid bilayer and as a consequence cause functional alterations on the cytoplasmic membrane of S. epidermidis cells.en
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.relation.ispartofseriesPlanta Med 2011; 77
dc.rightsLicencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES
dc.titleAntibacterial properties of Phenolic triterpenoids against staphylococcus epidermidis
dc.typeinfo:eu-repo/semantics/article
dc.subject.keywordpristimerol
dc.subject.keyword8‑epi‑6‑deoxoblepharodol
dc.subject.keywordCelastraceae
dc.subject.keywordStaphylococcus epidermidis
dc.subject.keywordantibacterial activity
dc.subject.keywordmembrane disruption


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