Mostrar el registro sencillo del ítem

dc.contributor.authorTaddeo, Vito A.
dc.contributor.authorNúñez, Marvin J.
dc.contributor.authorBeltrán, Manuela
dc.contributor.authorCastillo, Ulises G.
dc.contributor.authorMenjívar, Jenny
dc.contributor.authorJiménez Díaz, Ignacio Antonio 
dc.contributor.authorAlcamí, José
dc.contributor.authorBedoya, Luis M.
dc.contributor.authorLópez Bazzocchi, Isabel
dc.date.accessioned2024-02-01T11:30:57Z
dc.date.available2024-02-01T11:30:57Z
dc.date.issued2021
dc.identifier.urihttp://riull.ull.es/xmlui/handle/915/35934
dc.description.abstractThe aim of the present study is to report the isolation, structural elucidation, and antiviral evaluation of four new withanolide-type steroids, named nicansteroidins A−D (1− 4), together with nine related known compounds (5−13) isolated from the aerial parts of Physalis nicandroides. Their structures were established based on an extensive spectroscopic analysis, including 1D and 2D NMR techniques. Outstandingly, nicansteroidins A and B possess an unusual side chain with an exocyclic double bond on the δ-lactone system, whereas nicansteroidins C and D have an uncommon cycloperoxide functionality in ring A as distinct structural motifs. Their biological evaluation as inhibitors of human immunodeficiency virus type 1 replication revealed that two compounds from this series, 7 and 13, displayed strong inhibition of HIV-1 replication with IC50 values lower than 2 μM. Moreover, cellular mechanism experiments showed that the main target of these compounds in the HIV replication cycle is viral transcription. This study is the first report of withanolide-type steroids as HIV inhibitors and provides insight into their potential as candidates for further preclinical studies.es_ES
dc.language.isoenes_ES
dc.relation.ispartofseriesJorunal of Nat.ural Products 2021, 84, 2717−2726;
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleWithanolide-Type Steroids from Physalis nicandroides Inhibit HIV Transcriptiones_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1021/acs.jnatprod.1c00637
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


Ficheros en el ítem

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Excepto si se señala otra cosa, la licencia del ítem se describe como Attribution-NonCommercial-NoDerivatives 4.0 Internacional