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dc.contributor.authorZeouk, Ikrame
dc.contributor.authorOuedrhiri, Wessal
dc.contributor.authorJiménez Díaz, Ignacio Antonio
dc.contributor.authorLorenzo Morales, Jacob
dc.contributor.authorLópez Bazzocchi, Isabel
dc.contributor.authorBekhti, Khadija
dc.date.accessioned2024-02-01T14:28:22Z
dc.date.available2024-02-01T14:28:22Z
dc.date.issued2020
dc.identifier.urihttp://riull.ull.es/xmlui/handle/915/35938
dc.description.abstractThe look for benefits antioxidant agents has attracted much attention from consumers, health and food industries. Certainly, the interactions occurring between different compounds affect the antioxidant efficiency. The current study aims the investigation of the antioxidant combined effect of Rhamnus alaternus fractions using DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) assay. The three most active fractions were subject for binary and ternary combinations using the augmented simplex-centroid design. Two known compounds emodin (1) and kaempferol (2) were identified from the ethanolic extract of the leaves of Rhamnus alaternus. Their structures were elucidated using spectroscopy data. The antioxidant potent of the crude extract and the mixture was compared with the antioxidant activity of the fractions separately. Important synergetic effects were observed in binary mixture between the most active fractions, besides the response optimizer allowed us to optimize the mixture presenting the highest antioxidant activity at 82.54 %. The results from the present work could have interesting applications in both medical formulations and functional food design.es_ES
dc.language.isoenes_ES
dc.relation.ispartofseriesIndustrial Crops & Products 144 (2020) 112054;
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleIntra-combined antioxidant activity and chemical characterization of three fractions from Rhamnus alaternus extract: Mixture designes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1016/j.indcrop.2019.112054
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.subject.keywordAntioxidantes_ES
dc.subject.keywordRhamnus alaternuses_ES
dc.subject.keywordFlavonoidses_ES
dc.subject.keywordAnthraquinoneses_ES
dc.subject.keywordMixture designes_ES
dc.subject.keywordSynergismes_ES
dc.subject.keywordFormulationes_ES
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional