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dc.contributor.authorGarcia-Mayea, Yoelsis
dc.contributor.authorMir Pérez, Cristina
dc.contributor.authorMuñoz-Hidalgo, Lisandra
dc.contributor.authorBenavente, Sergi
dc.contributor.authorCastellvi, Josep
dc.contributor.authorTemprana, Jordi
dc.contributor.authorMaggio, Valentina
dc.contributor.authorLorente, Juan
dc.contributor.authorPaciucci, Rosanna
dc.contributor.authorLleonart, Matilde E.
dc.date.accessioned2024-02-08T21:06:19Z
dc.date.available2024-02-08T21:06:19Z
dc.date.issued2019
dc.identifier.issn1460-2180
dc.identifier.urihttp://riull.ull.es/xmlui/handle/915/36161
dc.description.abstractTo identify the putative relevance of autophagy in laryngeal cancer, we performed an immunohistochemistry study to analyze the expression of the proteins involved in this process, namely, LC3, ATG5 and p62/SQSTM1. Additionally, Prostate tumor-overexpressed gene 1 protein (PTOV1) was included due to its potential relevance in laryngeal cancer. Moreover, as cancer resistance might involve autophagy in some circumstances, we studied the intrinsic drug resistance capacity of primary tumor cultures derived from 13 laryngeal cancer biopsies and their expression levels of LC3, ATG5, p62 and PTOV1. Overall, our results suggest that (i) cytoplasmic p62 and PTOV1 can be considered prognostic markers in laryngeal cancer, (ii) the acquisition of resistance seems to be related to PTOV1 and autophagy-related protein overexpression, (iii) by increasing autophagy, PTOV1 might contribute to resistance in this model and (iv) the expression of autophagy-related proteins could classify a subgroup of laryngeal cancer patients who will benefit from a therapy based upon autophagy inhibition. Our study suggests that autophagy inhibition with hydroxychloroquine could be a promising strategy for laryngeal cancer patients, particularly those patients with high resistance to the CDDP treatment that in addition have autophagy upregulation.en
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.relation.ispartofseriesCarcinogenesis, 2019, vol.40(12) pp. 1–10
dc.titleAutophagy inhibition as a promising therapeutic target for laryngeal canceren
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1093/carcin/bgz080
dc.subject.keywordLaryngeal canceren
dc.subject.keywordAutophagy inhibitionen


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