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dc.contributor.authorEchezarreta López, María Magdalena 
dc.contributor.authorPerdomo López, I.
dc.contributor.authorEstrada, E.
dc.contributor.authorVila-Jato, J.L.
dc.contributor.authorTorres-Labandeira, J.J.
dc.contributor.otherIngeniería Química y Tecnología Farmacéutica
dc.date.accessioned2024-04-29T20:05:41Z
dc.date.available2024-04-29T20:05:41Z
dc.date.issued2002
dc.identifier.urihttp://riull.ull.es/xmlui/handle/915/37314
dc.description.abstractThe interaction between dexamethasone sodium phosphate (DSP) and four cyclodextrin (CyD) derivatives [2,6-di-O-b-cyclodextrin (DIMEB), g-cyclodextrin (g-CyD), and hydroxypropyl-b-cyclodextrin with either 2.7 or 4.6 degrees of substitution (HPbCyD 2.7 and HPbCyD 4.6, respectively)] was investigated by proton nuclear magnetic resonance spectroscopy (1H NMR). The data suggested the formation of inclusion complexes in solution in which B andC rings ofthe moleculeare located inside the cavity. Nevertheless, the structure, in terms of depth within CyD, depends on the derivative considered. Molecular mechanics calculations of DSPcomplexes withDIMEB and g-CyD support the NMR results. The potential displacement of DSP from the CyD cavity by usual ophthalmic drugs (e.g., polymyxin B, trimethoprim, and benzalkonium chloride) was determined by NMR. The technique has been found useful to analyze this problem in pharmaceutical preparationsen
dc.description.sponsorshipFinanciado por Xunta de Galicia under project PGIDT99-PX120305
dc.description.sponsorshipLaboratorios Cusi
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.relation.ispartofseriesJournal of Pharmaceutical Sciences, Vol. 91, 1536–1547 (2002)
dc.rightsLicencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES
dc.titleUtility of nuclear magnetic resonance spectroscopy to characterize the structure of dexamethasone sodium phosphate inclusion complexes with cyclodextrins in solution and to analyze potential competitive effectsen
dc.typeinfo:eu-repo/semantics/article
dc.subject.keywordglucocorticoidsen
dc.subject.keywordcyclodextrinsen
dc.subject.keywordophthalmic solutionsen
dc.subject.keywordnuclear magnetic resonance spectroscopyen
dc.subject.keywordmolecular modelingen
dc.subject.keywordmicellesen


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Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
Except where otherwise noted, this item's license is described as Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)