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dc.contributor.authorEchezarreta López, María Magdalena 
dc.contributor.authorTorres-Labandeira, Juan J.
dc.contributor.authorSantana-Penín, Lourdes
dc.contributor.authorVila-Jato, José L.
dc.contributor.otherIngeniería Química y Tecnología Farmacéutica
dc.date.accessioned2024-04-30T20:05:08Z
dc.date.available2024-04-30T20:05:08Z
dc.date.issued1993
dc.identifier.urihttp://riull.ull.es/xmlui/handle/915/37326
dc.description.abstractPhase·solubility studies of the complexation of glibornuride (GB) with α-, β- and γ-cydodextrin (CyD) showed that the most stable complex is formed with β-CyD. The effects of β-CyD on chemical shift values in 1H-NMR spectra of GB in aqueous médium suggest that it ís the bornyl part of the drug which is bound inside the CyD cavity. Solid inclusion complexes were obtained by coprecipitation and freeze-drying methods, and characterized by X-ray diffractometry and differential scanning calorimetry. Druq solubility was improved by inclusion in solid complexes obtained by either methoden
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.relation.ispartofseriesEuropean Journal of Pharmaceutics and Biopharmaceutics, 39 (6)
dc.rightsLicencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES
dc.titleGlibornuride-ß-cyclodextrin inclusion complexes: Preparation, structural characterization and in vitro dissolution behaviouren
dc.typeinfo:eu-repo/semantics/article


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