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Glibornuride-ß-cyclodextrin inclusion complexes: Preparation, structural characterization and in vitro dissolution behaviour
dc.contributor.author | Echezarreta López, María Magdalena | |
dc.contributor.author | Torres-Labandeira, Juan J. | |
dc.contributor.author | Santana-Penín, Lourdes | |
dc.contributor.author | Vila-Jato, José L. | |
dc.contributor.other | Ingeniería Química y Tecnología Farmacéutica | |
dc.date.accessioned | 2024-04-30T20:05:08Z | |
dc.date.available | 2024-04-30T20:05:08Z | |
dc.date.issued | 1993 | |
dc.identifier.uri | http://riull.ull.es/xmlui/handle/915/37326 | |
dc.description.abstract | Phase·solubility studies of the complexation of glibornuride (GB) with α-, β- and γ-cydodextrin (CyD) showed that the most stable complex is formed with β-CyD. The effects of β-CyD on chemical shift values in 1H-NMR spectra of GB in aqueous médium suggest that it ís the bornyl part of the drug which is bound inside the CyD cavity. Solid inclusion complexes were obtained by coprecipitation and freeze-drying methods, and characterized by X-ray diffractometry and differential scanning calorimetry. Druq solubility was improved by inclusion in solid complexes obtained by either method | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | |
dc.relation.ispartofseries | European Journal of Pharmaceutics and Biopharmaceutics, 39 (6) | |
dc.rights | Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional) | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES | |
dc.title | Glibornuride-ß-cyclodextrin inclusion complexes: Preparation, structural characterization and in vitro dissolution behaviour | en |
dc.type | info:eu-repo/semantics/article |
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