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dc.contributor.authorAcebes Vindel, Ángel José 
dc.contributor.authorSeoane, Sara
dc.contributor.authorvan den Heuvel, Martijn
dc.contributor.authorJanssen, Niels 
dc.contributor.otherCiencias Médicas Básicas
dc.contributor.otherGrupo de investigación: Mecanismos Moleculares en Neurodegeneración, Instituto de tecnologías Biomédicas (ITB). Grupo propio de la Universidad de La Laguna. IP del grupo: Ángel Acebes
dc.date.accessioned2024-05-04T20:05:09Z
dc.date.available2024-05-04T20:05:09Z
dc.date.issued2024
dc.identifier.urihttp://riull.ull.es/xmlui/handle/915/37381
dc.description.abstractThe default mode network is a central cortical brain network suggested to play a major role in several disorders and to be particularly vulnerable to the neuropathological hallmarks of Alzheimer’s disease. Subcortical involvement in the default mode network and its alteration in Alzheimer’s disease remains largely unknown. We performed a systematic review, meta-analysis and empirical validation of the subcortical default mode network in healthy adults, combined with a systematic review, meta-analysis and network analysis of the involvement of subcortical default mode areas in Alzheimer’s disease. Our results show that, besides the well-known cortical default mode network brain regions, the default mode network consistently includes subcortical regions, namely the thalamus, lobule and vermis IX and right Crus I/II of the cerebellum and the amygdala. Network analysis also suggests the involvement of the caudate nucleus. In Alzheimer’s disease, we observed a left-lateralized cluster of decrease in functional connectivity which covered the medial temporal lobe and amygdala and showed overlap with the default mode network in a portion covering parts of the left anterior hippocampus and left amygdala. We also found an increase in functional connectivity in the right anterior insula. These results confirm the consistency of subcortical contributions to the default mode network in healthy adults and highlight the relevance of the subcortical default mode network alteration in Alzheimer’s disease.en
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.relation.ispartofseriesBrain Communications, Volume 6, Issue 2, 2024
dc.rightsLicencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES
dc.titleThe Subcortical Default Mode Network and Alzheimer's Disease: A systematic review and Activation Likelihood Estimation Meta-Analysis.en
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1093/braincomms/fcae128


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