Association between myocarditis and antipsychotics other than clozapine: A systematic literature review and a pharmacovigilance study using VigiBase

Abstract

Pharmacovigilance studies have definitely established that clozapine can cause myocarditis. Two published reviews suggested that on rare occasions other antipsychotics may induce myocarditis. This review explored myocarditis associated with antipsychotics other than clozapine by conducting a systematic search of the literature and critically analyzing the current data in VigiBase compared to the data on clozapine-associated myocarditis. VigiBase is the World Health Organization’s global pharmacovigilance database which uses as a statistical signal for associations a logarithmic measure of disproportionality called the information component (IC)