Glioma stem cells (GSCs) live in a continuous process of stemness reprogramming to achieve specific cell commitment
within the so-called GSC niches, specifically located in periarteriolar regions. In this review, we analyze the expression
levels, cellular and subcellular location, and role of three scaffold proteins (IQGAP1, FKBP51, and AmotL2) in GSC niches.
Scaffold proteins contribute to cell differentiation, migration, and angiogenesis in glioblastoma. It could be of diagnostic
interest for establishing stages, for therapeutic targets, and for improving glioblastoma prognosis, which is still at the
experimental level. (J Histochem Cytochem 70:9–16, 2022)
