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AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem Cell Niches

dc.contributor.authorMorales González, Manuel José
dc.contributor.authorRotoli, Deborah
dc.contributor.authorDíaz-Flores, Lucio
dc.contributor.authorGutiérrez, Ricardo
dc.contributor.authorÁvila, Julio
dc.contributor.authorMartín-Vasallo, Pablo
dc.contributor.otherMedicina Interna, Dermatología y Psiquiatría
dc.date.accessioned2024-11-10T21:05:19Z
dc.date.available2024-11-10T21:05:19Z
dc.date.issued2022
dc.identifier.urihttp://riull.ull.es/xmlui/handle/915/40024
dc.description.abstractGlioma stem cells (GSCs) live in a continuous process of stemness reprogramming to achieve specific cell commitment within the so-called GSC niches, specifically located in periarteriolar regions. In this review, we analyze the expression levels, cellular and subcellular location, and role of three scaffold proteins (IQGAP1, FKBP51, and AmotL2) in GSC niches. Scaffold proteins contribute to cell differentiation, migration, and angiogenesis in glioblastoma. It could be of diagnostic interest for establishing stages, for therapeutic targets, and for improving glioblastoma prognosis, which is still at the experimental level. (J Histochem Cytochem 70:9–16, 2022)en
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.relation.ispartofseriesJournal of Histochemistry & Cytochemistry 2022, Vol. 70(1)
dc.rightsLicencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES
dc.titleAmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem Cell Niches
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1369/00221554211025480
dc.subject.keywordAmotL2
dc.subject.keywordIQGAP1
dc.subject.keywordFKBP51
dc.subject.keywordangiogenesis
dc.subject.keywordglioblastoma stem cells
dc.subject.keywordscaffold proteins
dc.subject.keywordstem cell niche
dc.subject.keywordstemness
dc.subject.keywordtumor heterogeneity
dc.subject.keywordtumor immune infiltrate
dc.subject.keywordtumor microenvironment


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Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
Except where otherwise noted, this item's license is described as Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)