Urate oxidase is an endogenous enzyme found in most
mammals but not in humans. Urate oxidase catalyzes the
enzymatic oxidation of uric acid into allantoin, a metabolite
that is 5–10 times more soluble in urine than uric acid. With
complementary DNA technology it is possible to produce large
quantities of the pure recombinant protein [1]. Rasburicase
(RS), a recombinant form of urate oxidase, has been
demonstrated to be superior to allopurinol in the control of
uric acid production associated with acute leukemias and
high-grade lymphomas
