Biological Predictors of Chemotherapy Induced Peripheral Neuropathy (CPIN): MASCC Neurological Complications Working Group Overview. Support care Cancer

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating condition associated with a number of chemotherapeutic agents. Drugs commonly implicated in development of CIPN include platinum agents, taxanes, vinca alkaloids, bortezomib, and thalidomide analogues. As response to the same drug can vary between individuals, it is hypothesized that an individual’s specific genetic variants could impact regulation of genes involved in drug pharmacokinetics, ion channel functioning, neurotoxicity, and DNA repair, which in turn affect CIPN development and severity. Variations of other molecular markers may also affect the incidence and severity of CIPN. Hence, the objective of this review is to summarize the known biological (molecular and genomic) predictors of CIPN and discuss means to facilitate progress in this field.