In this work, a regional-scale strategy to characterize the radon activity levels in the Canary Islands (Spain) is described. The main objectives of this strategy consisted of (1) studying the likely relationship between radon concentration and lithology of the rock matrix through the lithological data of 247 samples from volcanic rocks of the Canary Islands and (2) implementing a series of monitoring sites in the form of boreholes and wells to study the evolution of radon-in-air activity on a daily to yearly timescale.