RT info:eu-repo/semantics/bachelorThesis
T1 Estudio de la reacción de Sonogashira y su aplicación a la síntesis de fármacos
A1 Baz Figueroa, Aarón
K1 Reacción de Sonogashira, Síntesis orgánica, Tecnología farmacéutica.
AB Thanks to organic synthesis it´s posible to obtain in the laboratory numerouschemical structures of great interest, that by natural source could only beobtained on a small scale. However, there are chemical compounds that presentgreat difficulty to be obtained by classical methods, and require the use of newmethods of synthesis.The formation of classical carbon-carbon links, used as carbon nucleophilic,organolithium or Grignard reagents, and as carbon electrophilic, deficientspecies carbonyl type (nucleophilic addition), or halides or alkyltrifluoromethansulphonates (nucleophilic substitution). However, the reactionson aryls, heteroaryls, alkenes and alkynes were not produced or had manylimitations.The transition metal complexes have greatly expanded the horizon of syntheticorganic chemistry, by successfully achieving carbon-carbon couplings that wereso far reduced, being the “palladium” the most used transition metal.Within the wide variety of carbon-carbon coupling reactions catalyzed bypalladium, one of the most used is the reaction of Sonogashira, with implies thealkynes coupling. This reaction has been applied to the synthesis of a largenumber of complex molecules, natural products and biologically activecompounds, with excellent yields and selectivity, it´s therefore interesting tostudy when it comes to meeting the growing demand for new substances for thedevelopment of drugs.
YR 2019
FD 2019
LK http://hdl.handle.net/915/15995
UL http://hdl.handle.net/915/15995
LA es
DS Repositorio institucional de la Universidad de La Laguna
RD 22-nov-2024