RT info:eu-repo/semantics/bachelorThesis
T1 Nuevas terapias moleculares en la lucha contra la enfermedad de Alzheimer
A1 Delgado Gómez, Sara
K1 Alzheimer, Tratamiento
AB Alzheimer's is a neurodegenerative disease that affects millions of individuals. Despiteinvolving a diversity of risk factors and being related to the lifestyle, the longevity seems tobe the most relevant one.Even though it is currently incurable, there exists a symptomatic treatment. Until the lastdecade, most studies has focused on anatomopathological markers: the plaques of betaamyloid peptide and the tangles of the Tau protein.Due to this lack of an effective treatment, the researchers have been attempting tocharacterize new Alzheimer's biomarkers. The Final Project has evaluated: 1)themodifications in the retina microvasculature, which offers a possibility to brain changes,and 2)the alterations of the light neurofilament protein levels. This protein is not onlyreleased when the neurodegenerative processes are present, but also 16 years before thesymptoms of the disease appear.In addition, we have also assessment the AMBAR study, as a new treatment againstAlzheimer's. It consists of a plasma replacement for therapeutic albumin in order tofacilitate the elimination of beta-amyloid peptide. Finally, it has been analysed a greatnovel scientific approach related to the hippocampal neurogenesis in adults, that is presentup to 90 years and also seems to be reduced in Alzheimer´s pacients.
YR 2019
FD 2019
LK http://riull.ull.es/xmlui/handle/915/16016
UL http://riull.ull.es/xmlui/handle/915/16016
LA es
DS Repositorio institucional de la Universidad de La Laguna
RD 08-nov-2024