RT info:eu-repo/semantics/bachelorThesis
T1 Uso terapéutico de la vacuna BCG
A1 Cruz González, José Antonio
K1 Bacilo de Calmette-Guérin, Tratamientos contra el cáncer.
AB The tuberculosis vaccine contains an attenuated strain of Mycobacterium bovis knownas Bacillus of Calmette and Guerin (BCG). It is the most widely employed vaccineworldwide, although its efficacy is variable. BCG is also a powerful immunomodulatingagent, which has opened up the possibilities of its use in the treatment of other diseases,particularly in the treatment of some types of cancer. After its approval in 1990, theBCG has been used as an effective treatment for bladder cancer. The mechanism bywhich it exerts its anticancer effect is still unknown, although it is probably based in thefact that the cells infected by the vaccine´s bacteria secrete a number of cytokines thatlead to the destruction of the tumor cells. However, although BCG has been shown todelay the recurrence of bladder cancer, this treatment does not allow to achieve acomplete cure of the disease.Besides its effectiveness in the treatment of bladder cancer, there are preclinical andclinical evidences of the potential usefulness of the BCG vaccine for other types ofcancer, particularly in melanoma, gastric cancer and colon cancer. In this work, areview of the literature on the use of BCG as anticancer agent, as well as on its potentialapplication in other therapies has been carried out.
YR 2019
FD 2019
LK http://riull.ull.es/xmlui/handle/915/16036
UL http://riull.ull.es/xmlui/handle/915/16036
LA es
DS Repositorio institucional de la Universidad de La Laguna
RD 04-may-2024