RT info:eu-repo/semantics/bachelorThesis
T1 Propiedades físicas de las cápsides virales icosaédricas: modelos de potenciales de interacción y constantes de fuerza.
A1 Bacallado Rivero, Adrián
AB Virology is a research field that needs physics to understand the behaviour ofviruses, since there are a lot mechanisms that use thermodynamics, kinetics orelectrostatics. These are some of the viral properties that we are going to studyand explain.In this final degree work, we will start explaining the viruses in their fundamentals, introducing the capsids, the envelope of the viruses. We will consideronly the case of the icosahedral viruses, since this geometrical form is the onethat appears the most in nature. These capsids are formed by protein subunits, thecapsomers. Icosahedral capsids are described by Caspar and Klug’s models, sincethey introduce the triangular number T, a very important parameter in virology.One of the most fastinating feature is the auto-assembly of viral capsids. This is afeature that we will explain via thermodynamics and kinetics.We will study as well the electrostatic interaction between the capsomers andthe capsomers in the formed capsid through Poisson-Bolztmann’s equation. Another physical feature that we will study is the mechanical properties. Viruses endure external forces in their environment and the osmotic pressure that the genomeapplies to the capsid. That force can be measured and studied.The main focus of this work will be on the models that explain the interaction potential. First, we will explain the two different models that explain theseinteractions: Coarse-grained and All-atom. Then, we will explain our two-bodyinteraction model, that is a Coarse-grained type, using trimers, a kind of triangular capsomers. Afterwards, we will introduce the variables that characterize thetrimer orientation and the equilibrium conditions that fixes the privileged orientation of the trimers in order to form a capsid. Then, we will calculate the secondderivative matrix of the interaction potential in order to calculate the force constants. Finally, we apply the equilibrium conditions to the matrix to obtain the forceconstants.
YR 2019
FD 2019
LK http://riull.ull.es/xmlui/handle/915/16257
UL http://riull.ull.es/xmlui/handle/915/16257
LA es
DS Repositorio institucional de la Universidad de La Laguna
RD 24-nov-2024