RT info:eu-repo/semantics/bachelorThesis
T1 Aplicaciones terapéuticas del trasplante de microbiota fecal
A1 Conde San Gil, Lucía
K1 Trasplante de microbiota fecal,  Clostridium difficile.
AB Introduction: In the recent years there has been an increase in the number of studies toevaluate the possibility of using the faecal microbiota transplantation (FMT) as a therapyfor different diseases. This has been due to the growing knowledge on the relationshipbetween the gastrointestinal microbiota and health and, therefore, on the role of dysbiosis(the alteration of the microbiota composition or function) in the development of severaldiseases.Objectives and Methodology: In the present work, a bibliographic search was carriedout by using the point-Q searcher of the University of La Laguna Library to evaluate thepossible therapeutic applications of FMT in some intestinal pathologies, particularly inthe colitis by Clostridium difficile (CDI), in the Inflammatory Bowel Disease (includingboth Ulcerative Colitis and Crohn´s Disease) as well as in the Irritable Bowel Syndrome.Results, Discussion and Conclusions: In the three diseases studied the FMT techniquehas been effective in some of the cases, particularly in the treatment of CDI, in which theefficacy of this treatment is around 80-90% in those cases of patients unresponsive toantibiotics or with recurrent infection. In the other diseases the obtained results have notbeen so positive and additional studies are needed to drive out valid conclusions and toclarify technical aspects such as the best administration route, the sample preparation, orthe safety profile, among others, with the aim of standardizing the process and to establishoptimal treatment protocols.
YR 2019
FD 2019
LK http://riull.ull.es/xmlui/handle/915/17514
UL http://riull.ull.es/xmlui/handle/915/17514
LA es
DS Repositorio institucional de la Universidad de La Laguna
RD 08-nov-2024