RT info:eu-repo/semantics/bachelorThesis
T1 Estudio de la solubilidad en medio acuoso de la zoantamina, un alcaloide marino bioactivo
A1 Ferrigni, Elenia
K1 Zoanthus sp., Zoantamina, Alcaloide marino.
AB My thesis is focused on a project that has been working for a few years. The discovery andextraction of some metabolisms from some polyps present in Pacific, Atlantic and Indian oceans,has revolutionized the problem of osteoporosis. This is a disease that affects the cells in the bones.There is a decrease in osteoblasts and increase in osteoclasts which are essential for bonemaintenance and growth. With the extraction of these two molecules (marine alkaloids)zoanthamine and norzoanthamine the activity of these molecules has been verified as preventori andfor the treatment of osteoporosis, but unfortunately, the chemical-physical properties are not yetknown, therefore the pharmacokinetics, which allow us to create slow release formulations that canbe effective for treatment. For this reason, before moving to the formulation and implantation inanimals, this condition must first be verified.My work was based on the extraction of these polyps and then on their purification to get enoughpure samples of two alkaloids and to be able to perform some physico-chemical tests such as:solubility, thermolability, pH variation, etc. The purification methodology carried out was based onthin layer chromatography, chromatographic columns and HPLC. The results were confirmed byNMR (nuclear magnetic resonance) and UV (ultraviolet spectroscopy).
YR 2019
FD 2019
LK http://riull.ull.es/xmlui/handle/915/17520
UL http://riull.ull.es/xmlui/handle/915/17520
LA es
DS Repositorio institucional de la Universidad de La Laguna
RD 21-may-2024