RT info:eu-repo/semantics/bachelorThesis
T1 Microfluídica para la elaboración de nanopartículas híbridas
A1 Dorta Hernández, María
K1 Microfluídica, Nanopartículas híbridas
AB Nanoparticles have been traditionally elaborated by bulk nanoprecipitation, a method wherecomponents are mixed in the macroscale, which results in batches with wide polydispersity ofsizes and relatively large diameters. An alternative to these techniques is microfluidics, wheremixing is carried out in a smaller scale using microchannels, being diffussion the physicalphenomena that governs the mixing process. This results on batches with smaller sizes anddistribution.In this work we study the influence of a summon of factors such as flow rate ratio, total flowrate and the solvent evaporation phase on size and polydispersity index of nanoparticles madeof poly (D,L- lactic acid-co-glycolic) (PLGA) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine 2000 (DSPE-MPEG2000). A size reduction and polydispersity index augmentationwere observed when flow rate ratio and total flow rate were increased. Likewise, a size reduction of nanoparticles was found after the solvent evaporation phase, especially in batches wherea larger flow rate of organic phase was used.
YR 2020
FD 2020
LK http://riull.ull.es/xmlui/handle/915/19993
UL http://riull.ull.es/xmlui/handle/915/19993
LA es
DS Repositorio institucional de la Universidad de La Laguna
RD 23-abr-2024