RT info:eu-repo/semantics/bachelorThesis
T1 Early pharmacological profiling of ATB0,+ inhibitors.
A1 Medina Alonso, Ithaisa
A2 Grado En Biología
K1 ATB0
K1 +
K1 SCL6A14
K1 amino acid transporter
K1 antitumor activity
K1 glutamic acid based dipeptides
K1 Betti bases
K1 ATB0,+
K1 SCL6A14
K1 amino acid transporter
K1 antitumor activity
K1 glutamic acid based dipeptides
K1 Betti bases
AB Cancer  cells  experiment  an  overexpression  of  amino  acid  transporters  to  support  the increasing demand of amino acids. ATB0,+ transporter up-regulation has been identified in multiple tumors. This transporter constitutes a possible selective therapeutic target to treat cancer. Two families of molecules, naphtol-derived Betti bases and glutamic acid based dipeptides  seems  to  behave  as  ATB0,+  inhibitors.  This  project  aims  to  explore  the interaction between the ATB0,+ transporter and the mentioned compounds. To do this we will evaluate their interaction with ATB0,+ through computational approaches. We will also realize a colony formation analysis and a cell cycle analysis. Functional expression studies will be carried out in mammalian cells and electrophysiological tests will be realized on Xenopus  laevis. Finally, autophagy and expression levels of the CHOP and ASNS genes will be analyzed as a read out of amino acid starvation.
YR 2020
FD 2020
LK http://riull.ull.es/xmlui/handle/915/20071
UL http://riull.ull.es/xmlui/handle/915/20071
LA es
DS Repositorio institucional de la Universidad de La Laguna
RD 28-nov-2024