RT info:eu-repo/semantics/bachelorThesis
T1 Discovery Of Selective Inhibitors Of SLC6A14
A1 Díaz Pérez, Juan Benamer
K1 Transportador de aminoácidos SLC6A14, Dipéptidos.
AB Amino acids play a key role in human biology. Currently they are object of studybecause they are involved in various proliferative diseases, including cancer. The amino acidtransporter SLC6A14 has been identified overexpressed in diverse tumors. SLC6A14represents a druggable target for cancer treatment. However, there is only one reportedinhibitor of the protein, α-methyltryptophan, which has very low potency. Thus, inhibitors ofSLC6A14 are in need.In this study we planned the preparation of a small library of tryptophan-baseddipeptides (TBDs). The compounds were designed based on the previous results of the group.In addition to TBDs, we prepared a fluorescent derivative of tryptophan. We chose dansyl asfluorescent group. A fluorescent probe was synthesized, characterized and tested in vitroagainst human solid tumor cells. The results indicate that the fluorescent compound is notsuitable for SLC6A14 inhibition assays.
YR 2020
FD 2020
LK http://riull.ull.es/xmlui/handle/915/20478
UL http://riull.ull.es/xmlui/handle/915/20478
LA es
DS Repositorio institucional de la Universidad de La Laguna
RD 19-abr-2024