RT info:eu-repo/semantics/article
T1 Evaluation of in vitro corrosion resistance and in vivo osseointegration properties of a FeMnSiCa alloy as potential degradable implant biomaterial
A1 Souto, Ricardo Manuel
A1 Trincă, Lucia Carmen
A1 Burtan, Liviu
A1 Mareci, Daniel
A1 Fernández Pérez, Bibiana María
A1 Stoleriu, Iulian
A1 Stanciu, Teodor
A1 Stanciu, Sergiu
A1 Solcan, Carmen
A1 Izquierdo Pérez, Javier
A2 Química
A2 Grupo de Electroquímica y Corrosión
Departamento de Química
Instituto de Materiales y Nanotecnología
K1 biodegradable implant materials
K1 surface characterization
K1 corrosion resistance
K1 FeMnSiCa alloy
K1 FeMnSi alloy
K1 osseointegration
AB In vitro electrochemical characterization and in vivo implantation in an animalmodel were employed to evaluate the degradation behavior and the biological activity ofFeMnSi and FeMnSiCa alloys obtained using UltraCast (Ar atmosphere) melting.Electrochemical characterization was based on open circuit potential measurement,electrochemical impedance spectroscopy and potentiodynamic polarization techniqueswhile the alloys were immersed in Ringer’s solution at 37 ºC for 7 days. Higher corrosionrates were measured for the Ca-containing material, resulting from inefficient passivationof the metal surface by oxy-hydroxide products. In vivo osseointegration was investigatedon a tibia implant model in rabbits by referring to a standard control (AISI 316L) stainlesssteel using standard biochemical, histological and radiological methods of investigation.Changes in the biochemical parameters were related to the main stages of the bone fracturerepair, whereas implantation of the alloys in rabbit’s tibia provided the necessarymechanical support to the injured bone area and facilitated the growth of the newlyconnective tissue, as well as osteoid formation and mineralization, as revealed by computedtomography reconstructed images and validated by the bone morphometric indices. Thepresent study highlighted that the FeMnSiCa alloy promotes better osteoinduction andosseointegration processes when compared to the base FeMnSi alloy or with AISI 316L,and in vivo degradation rates correlate well with corrosion resistance measurements inRinger’s solution.
YR 2020
FD 2020
LK http://riull.ull.es/xmlui/handle/915/20999
UL http://riull.ull.es/xmlui/handle/915/20999
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 20-abr-2024