RT info:eu-repo/semantics/article
T1 Mucin-Grafted Polyethylene Glycol Microparticles Enable Oral Insulin Delivery for Improving Diabetic Treatment
A1 Mumuni, Momoh A.
A1 Calister, Ugwu E.
A1 Aminu, Nafiu
A1 Franklin, Kenechukwu C.
A1 Musiliu, Adedokun O.
A1 Usman, Mohammed
A1 Abdulmumuni, Barikisu
A1 James, Oyeniyi Y.
A1 Ofokansi, Kenneth C.
A1 Anthony, Attama A.
A1 Ibezim, Emmanuel C.
A1 Díaz Díaz, David
K1 insulin
K1 mucin
K1 polyethylene glycol
K1 microparticles
K1 toxicology
K1 insulina
K1 mucina
K1 polietilenglicol
K1 micropartículas
K1 toxicología
AB In this study, different ratios of mucin-grafted polyethylene-glycol-based microparticleswere prepared and evaluated both in vitro and in vivo as carriers for the oral delivery of insulin.Characterization measurements showed that the insulin-loaded microparticles display irregularporosity and shape. The encapsulation efficiency and loading capacity of insulin were >82%and 18%, respectively. The release of insulin varied between 68% and 92% depending on themicroparticle formulation. In particular, orally administered insulin-loaded microparticles resulted ina significant fall of blood glucose levels, as compared to insulin solution. Subcutaneous administrationshowed a faster, albeit not sustained, glucose fall within a short time as compared to the polymericmicroparticle-based formulations. These results indicate the possible oral delivery of insulin usingthis combination of polymers.
PB MDPI
YR 2020
FD 2020
LK http://riull.ull.es/xmlui/handle/915/21301
UL http://riull.ull.es/xmlui/handle/915/21301
LA en
NO Tertiary Education Trust Fund (TETFUND)–National Research Fund (NFR)
DS Repositorio institucional de la Universidad de La Laguna
RD 23-abr-2024