RT info:eu-repo/semantics/bachelorThesis
T1 Dimorfismo sexual en un modelo de síndrome metabólico
A1 Beitia de Busturia, Miren
AB The Metabolic Syndrome (MetS) is a group of disorders constituted by obesity of centraldistribution, dyslipidemia, increase in blood pressure, hyperglycemia and insulin resistance.Since lifestyle and genes are key in its development, in order to avoid MetS it isrecommended to combine a healthy lifestyle through a correct diet and aerobic exercise. Theserum and glucocorticoid-inducible kinase 1 (SGK1) would be involved in MetSdevelopment. This kinase expression is regulated by hormones such as gluco- and mineralocorticoids and, at the transcriptional level, by osmotic and glucose changes. Previous datapublished by my supervisors have shown as SGK1 overexpression in a model of laboratorymice (B6.Tg.sgk1) is able to reproduce MetS. As there are differences in age and prevalencebetween sexes in humans, it suggests that sexual hormones may play an important role inMetS causes and/or development, the aims of this project are A) to review the state of the artsomething to do with the implications of sexual hormones in MetS, B) to elaborate anexperimental design in order to research if sexual hormones are able to modify some wellknown parameters related to MetS. To this purpose, we propose to study in two strains ofadult laboratory mice (Wild type, WT, and transgenic one overactivated for SGK1,B6.Tg.sgk1) which will be grouped by sexes and fed under a high and low fat diet,respectively, and treated with three different dosage of EMD63863 (inhibitor of SGK1activity). In order to expanding the level of knowledges on sexual hormones and MetS, wepropose a similar pattern design using human as experimental subjects.
YR 2020
FD 2020
LK http://riull.ull.es/xmlui/handle/915/21675
UL http://riull.ull.es/xmlui/handle/915/21675
LA es
DS Repositorio institucional de la Universidad de La Laguna
RD 27-abr-2024