RT info:eu-repo/semantics/masterThesis
T1 Transactive response DNA-binding Protein-43 (TDP-43) involvement in the Phosphatidylinositol-3-Kinase pathway.
A1 Santana Cordón, Laura
A2 Máster Universitario en Biomedicina Por la Universidad de la Laguna
AB Amyotrophic lateral sclerosis (ALS) is a mortal neurodegenerative disease andtogether with frontotemporal dementia (FTD) they are considered a part of the samespectrum of diseases collectively called TDP-43 proteinopathies, since they haveseveral pathological characteristics in common. One of the main characteristics thatdefine ALS is the loss of TDP-43 from the nucleus and its accumulation in thecytoplasm, forming inclusions. Since the PI3K/AKT pathway is neuroprotective andcontrols a prosynaptogenic program, this pathway is important in the study of ALSpathogenesis. The usage of a PI3K pathway activating transduction peptide (PTD4-PI3KAc) as a pharmacological tool offers us the possibility of studying the possiblefunctional interactions between TDP-43 and the PI3K pathway. Thanks to the use of aan allelic series of Knock-In mice with point mutations in the Tardbp/TDP-43 gene andthe use of the activating peptide, we can study how the activation of the PI3K pathwaycan influence the different mutations in TDP-43
YR 2021
FD 2021
LK http://riull.ull.es/xmlui/handle/915/23110
UL http://riull.ull.es/xmlui/handle/915/23110
LA es
DS Repositorio institucional de la Universidad de La Laguna
RD 26-dic-2024