RT info:eu-repo/semantics/masterThesis T1 Differences in functional connectivity of hippocampus between a group of low and high physical activity A1 Sánchez Rodríguez, Lucia A2 Máster Universitario en Biomedicina Por la Universidad de la Laguna AB Physical activity (PA) has been considered an important part of a healthy lifestyledue to the positive influence on an individual’s health. The physical benefits that we couldobtain from an active lifestyle are well-known and also, an overall wellbeing. Recentstudies have focused on the underlying changes in brain structure and function to explainthe benefits in cognition and mental health. To understand these changes, many studies aredone with rodents, using techniques normally invasive or applied to measure molecular orcellular changes in the brain, obtaining micro-scale findings difficult to demonstrate invivo human studies. In this study, we focused on a brain structure called the hippocampusin order to observe the functional differences in human brain influenced by PA duringwork compared to PA during leisure time. To do that, we used fMRI to detect blood flowdifferences between these two groups. Our results point to consider PA in work is relatedto greater left hippocampal activity than participants with low PA in work. The main pointof our study is the possible of stimulating newborn cells, known as neurogenesis,challenging us to think on PA as a possible treatment to Alzheimer’s disease in amultidomain intervention and also as a part of a lifestyle that could contribute to healthyaging YR 2021 FD 2021 LK http://riull.ull.es/xmlui/handle/915/23111 UL http://riull.ull.es/xmlui/handle/915/23111 LA en DS Repositorio institucional de la Universidad de La Laguna RD 23-abr-2024