RT info:eu-repo/semantics/masterThesis
T1 Volumetric variations on Hippocampal Subfields due to Physical Activity: a high-resolution MRI study
A1 Lozano Seoane, Sara
A2 Máster Universitario en Biomedicina Por la Universidad de la Laguna
AB Physical activity produces cognitive and structural changes in the brain. Itcauses effects on vascularization, neurogenesis and cognition, and these effects are related to each others. Previous studies have shown that an important part of these effects occur in the hippocampal formation, in humansand non-human animal models. But the hippocampal formation is a nonhomogeneous structure divided in several subregions, due to their differentcellular compositions and projections direction. The different impacts thatexercise may play on the hippocampal formation’s subregions in humans isnot well understood.In this study we examine the effects different types of regular physical activity have on hippocampal formation’s subregions volume. To this end, wemake use of high-resolution T1 and T2 MRI acquisition, along with a newautomated segmentation tool based on a computational atlas. We found apositive effect of regular occupational physical activity on the volume of DGand CA4 (hilus). In previous studies, increasing volume in the hippocampus has been accompanied by an enhancement of cognitive function, andless consistently, with human neurogenesis. Our results suggest that occupational activity is key in this increasing volume.
YR 2021
FD 2021
LK http://riull.ull.es/xmlui/handle/915/23634
UL http://riull.ull.es/xmlui/handle/915/23634
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 22-nov-2024