RT info:eu-repo/semantics/bachelorThesis
T1 Early pharmacological profiling of SLC6A14 inhibitors
A1 Fumero Cruz, Patricia
A2 Grado En Farmacia
K1 SLC6A14
K1 Cáncer
K1 Transportador SLC6A14
K1 Inhibidores
K1 Detección
AB One of the hallmarks of cancer is its deregulated metabolism. Cancer cells achievetheir required increased amount of energy by using different methods. One of them isoverexpressing amino acids transporters, such as SLC6A14 transporter. At present, thereis only one reported inhibitor of the protein, α-methyltryptophan, which shows very lowpotency. The lack of a method to detect SLC6A14 inhibitors might explain the scarcity ofavailable inhibitors. In this study, we tested four candidate fluorescent probes in an effortto develop a method to detect small molecule inhibitors of SLC6A14. Colony formationassay, chemosensitivity testing and fluorescence microscopy are used to detect theireffects. Results showed that the probes are not good substrates for the method.
YR 2021
FD 2021
LK http://riull.ull.es/xmlui/handle/915/24068
UL http://riull.ull.es/xmlui/handle/915/24068
LA es
DS Repositorio institucional de la Universidad de La Laguna
RD 28-nov-2024