RT info:eu-repo/semantics/bachelorThesis T1 Preparación de dicetopiperazinas y evaluación de su actividad antimicrobiana A1 Ríos Arceo, Xabier K1 Dicetopiperazina K1 Antimicrobiano K1 Dipéptido K1 Dicetopiperazinas K1 Actividad antimicrobiana AB Due to the increasing emergence of antibiotic resistance, there is a need to find new compounds to which these microorganisms are susceptible. 2,5-diketopiperazines are involved in various biological processes, and display from antimicrobial effects to anticancer activity. In this work, the synthesis of DKP derivatives from commercial alpha-amino acids such as ornithine, valine, leucine, alanine, serine and phenylalanine has been carried out by forming linear dipeptides and then cyclising them. The antimicrobial activities of the obtained DKPs were studied, using bacteria of high sanitary importance such as Escherichia coli (Gram -) and Staphylococcus aureus (Gram +). The deprotection step of the amine group of the amino acid ornithine could not be carried out, so the biological tests were performed with the compounds with the protected amine group. None of the compounds tested as antimicrobials had relevant activity, perhaps because a free amine group of ornithine is required for antimicrobial activity. YR 2022 FD 2022 LK http://riull.ull.es/xmlui/handle/915/29022 UL http://riull.ull.es/xmlui/handle/915/29022 LA es DS Repositorio institucional de la Universidad de La Laguna RD 29-mar-2024